Week 2 of the NFL season started last night with the last-second defensive thriller between the NFC South rivals Carolina Panthers and Tampa Bay Buccaneers.
To prepare for the rest of Week 2, NFL betting lines for every matchup are provided below for this Sunday and Monday. Each game listed features the spread, over/under, odds, and game information.
If the spreads hold up, every game in Week 2– except for the Ravens-Cardinals and Patriots-Dolphins games– should be single-digit battles like last night’s game.
The most compelling game this weekend is last year’s NFC Championship rematch between the New Orleans Saints and Los Angeles Rams. Following a no-call on a blatant defensive passing interference penalty, the Saints were not able to score, eventually resulting in a Rams win. This even led to the league changing rules surrounding PI challenges.
Nevertheless, the Rams are 2-point favorites at home Sunday afternoon. But expect the Saints to seek revenge and prove that they were cheated out of a Super Bowl birth last season.
NFL Week 2 Betting Lines
Indianapolis Colts vs. Tennessee Titans
- Spread: TEN -3
- Over/Under: 44
- Odds: TEN 60.30%, IND 39.70%
- Kickoff: Sunday, September 15 at 1:00 pm ET on FOX
- Location: Nissan Stadium ‒ Nashville, TN
Los Angeles Chargers vs. Detroit Lions
- Spread: LAC -2
- Over/Under:5
- Odds: LAC 54.03%, DET 45.97%
- Kickoff: Sunday, September 15 at 1:00 pm ET on CBS
- Location: Ford Field ‒ Detroit, MI
Buffalo Bills vs. New York Giants
- Spread: BUF -1.5
- Over/Under: 44
- Odds: BUF 52.28%, NYG 47.73%
- Kickoff: Sunday, September 15 at 1:00 pm ET on CBS
- Location: MetLife Stadium ‒ East Rutherford, NJ
Arizona Cardinals vs. Baltimore Ravens
- Spread: BAL -13
- Over/Under: 46
- Odds: ARI 85.47%, BAL 14.53%
- Kickoff: Sunday, September 15 at 1:00 pm ET on FOX
- Location: M&T Bank Stadium ‒ Baltimore, MD
New England Patriots vs. Miami Dolphins
- Spread: NE -19.5
- Over/Under:5
- Odds: NE 93.95%, MIA 6.05%
- Kickoff: Sunday, September 15 at 1:00 pm ET on CBS
- Location: Hard Rock Stadium ‒ Miami Gardens, FL
Dallas Cowboys vs. Washington Redskins
- Spread: DAL -6
- Over/Under:5
- Odds: DAL 70.05%, WAS 29.95%
- Kickoff: Sunday, September 15 at 1:00 pm ET on FOX
- Location: FedEx Field ‒ Landover, MD
Jacksonville Jaguars vs. Houston Texans
- Spread: HOU -8.5
- Over/Under:5
- Odds: HOU 78.25%, JAX 21.75%
- Kickoff: Sunday, September 15 at 1:00 pm ET on CBS
- Location: NRG Stadium ‒ Houston, TX
Seattle Seahawks vs. Pittsburgh Steelers
- Spread: PIT -3.5
- Over/Under: 47
- Odds: PIT 63.23%, SEA 36.77%
- Kickoff: Sunday, September 15 at 1:00 pm ET on FOX
- Location: Heinz Field ‒ Pittsburgh, PA
San Francisco 49ers vs. Cincinnati Bengals
- Spread: CIN -1.5
- Over/Under:5
- Odds: CIN 52.95%, SF 47.05%
- Kickoff: Sunday, September 15 at 1:00 pm ET on CBS
- Location: Paul Brown Stadium ‒ Cincinnati, OH
Minnesota Vikings vs. Green Bay Packers
- Spread: GB -2.5
- Over/Under:5
- Odds: GB 56.44%, MIN 43.56%
- Kickoff: Sunday, September 15 at 1:00 pm ET on FOX
- Location: Lambeau Field ‒ Green Bay, WI
Kansas City Chiefs vs. Oakland Raiders
- Spread: KC -7.5
- Over/Under:5
- Odds: KC 73.73%, OAK 26.27%
- Kickoff: Sunday, September 15 at 4:05 pm ET on CBS
- Location: RingCentral Coliseum ‒ Oakland, CA
New Orleans Saints vs. Los Angeles Rams
- Spread: LAR -2
- Over/Under: 52
- Odds: LAR 54.45%, NO 45.55%
- Kickoff: Sunday, September 15 at 4:25 pm ET on FOX
- Location: Los Angeles Memorial Coliseum ‒ Los Angeles, CA
Chicago Bears vs. Denver Broncos
- Spread: CHI -3
- Over/Under: 40
- Odds: CHI 58.26%, DEN 41.74%
- Kickoff: Sunday, September 15 at 4:25 pm ET on FOX
- Location: Empower Field and Mile High ‒ Denver, CO
Philadelphia Eagles vs. Atlanta Falcons
- Spread: PHI -2
- Over/Under: 5
- Odds: PHI 55.47%, ATL 44.53%
- Kickoff: Sunday, September 15 at 8:20 pm ET on NBC
- Location: Mercedes-Benz Stadium ‒ Atlanta, GA
Cleveland Brown vs. New York Jets
- Spread: CLE -6.5
- Over/Under: 44
- Odds: CLE 72.14%, NYG 27.86%
- Kickoff: Monday, September 16 at 8:15 pm ET on ESPN
- Location: MetLife Stadium ‒ East Rutherford, NJ
