Sports

2025 Sweet 16 Betting: All Four 1-Seeds Remain Alive

by
Samantha Gordon
March 24, 2025

members of Duke's basketball team huddling

The field of 68 has narrowed down to the Sweet 16 after 2+ rounds of play in the 2025 March Madness Tournament. All four 1-seeds and three 2-seeds remain in play for this year’s college basketball national championship.

The lowest remaining seed is the #10 Arkansas Razorbacks, who made it to the round of 16 by dispatching the #7 Kansas Jayhawks and the #2 St. John’s Red Storm.

The Sweet 16 games begin this Thursday, and March Madness betting sites have lines prepared for all eight matchups.

BYU (#6) vs. Alabama (#2)

Point Spread: BYU +4.5 (-110), Alabama -4.5 (-110)
Moneyline: BYU +155, Alabama -180
Over: 175.0 (-110)
Under: 175.0 (-110)
Thursday at 7:10 PM

Alabama is one of fourteen SEC programs that qualified for the tournament. The Crimson Tide is projected to beat BYU and move on to the Elite 8, as are four other SEC schools.

Maryland (#4) vs. Florida (#1)

Point Spread: Maryland +6.5 (-110), Florida -6.5 (-110)
Moneyline: Maryland +235, Florida -285
Over: 155.0 (-110)
Under: 155.0 (-110)
Thursday At 7:40 PM

The Florida Gators survived a close scare against the defending national champions, the UConn Huskies, in the second round but are favored by -6.5 against Maryland this Thursday.

Arizona (#4) vs. Duke (#1)

Point Spread: Arizona +9.0 (-110), Duke -9.0 (-110)
Moneyline: Arizona +340, Duke -460
Over: 153.5 (-110)
Under: 153.5 (-110)
Thursday at 9:40 PM

The Duke Blue Devils are the only remaining ACC team in the tournament. They also hold the best odds to win the championship, which would be their 6th in team history.

Arkansas (#10) vs. Texas Tech (#3)

Point Spread: Arkansas +5.5 (-110), Texas Tech -5.5 (-110)
Moneyline: Arkansas +195, Texas Tech -235
Over: 147.5 (-110)
Under: 147.5 (-110)
Thursday at 10:10 PM

The Texas Tech Red Raiders hold a -5.5-point edge in the spread against the Arkansas Razorbacks. This is our upset special of the Sweet 16.

Mississippi (#6) vs. Michigan State (#2)

Point Spread: Mississippi +3.0 (-110), Michigan State -3.0 (-110)
Moneyline: Mississippi +130, Michigan State -150
Over: 144.0 (-110)
Under: 144.0 (-110)
Friday at 7:09 PM

Another SEC underdog is the Mississippi Rebels, who are rated at 3 points worse than the Michigan State Spartans.

Kentucky (#3) vs. Tennessee (#2)

Point Spread: Kentucky +4.5 (-105), Tennesssee -4.5 (-115)
Moneyline: Kentucky +165, Tennessee -195
Over: 146.5 (-110)
Under: 146.5 (-110)
Friday at 7:39 PM

Two SEC powerhouses must battle it out in the Round of 16 this Friday. Tennessee is favored by -4.5, but it is always tough to wager against one of college basketball’s blue-blood programs so deep into the tourney.

Michigan (#5) vs. Auburn (#1)

Point Spread: Michigan +8.0 (-110), Auburn -8.0 (-110)
Moneyline: Michigan +290, Auburn -380
Over: 152.5 (-110)
Under: 152.5 (-110)
Friday at 9:39 PM

Auburn is the oldest team, on average, remaining in the tournament. Will their experience propel them beyond the Michigan Wolverines? The oddsmakers say yes.

Purdue (#4) vs. Houston (#1)

Point Spread: Purdue +8.0 (-110), Houston -8.0 (-110)
Moneyline: Purdue +285, Houston -370
Over: 133.0 (-110)
Under: 133.0 (-110)
Friday at 10:09 PM

The final contest of the Sweet 16 is the Purdue Boilermakers against the Houston Cougars. Houston is favored to win by 8 points and advance into the Elite 8.

2025 NCAA DI Men’s Basketball Tournament – National Champion