Two nationally ranked SEC programs will meet Saturday, October 17, as No. 13 Missouri travels to Oxford to face No. 9 Ole Miss. The highly anticipated matchup kicks off at 3:30 PM ET at Vaught-Hemingway Stadium, with the SEC Network carrying the game.
Missouri enters the contest with a 5-1 record after an impressive 27-6 win over Texas A&M. The Tigers have won two straight games against ranked opponents and are looking to strengthen their College Football Playoff credentials with another statement win.
Ole Miss enters at 4-1 after dismantling Vanderbilt 52-17 in its latest appearance. Under head coach Pete Golding, the Rebels have established themselves as legitimate SEC contenders, and Saturday’s matchup offers another chance to improve their postseason positioning.
Despite Missouri’s recent success, NCAAF sportsbooks have installed Mississippi as a six-point favorite. The betting lines suggest a relatively high-scoring contest, with the over/under set at 59 points.
Missouri vs. Mississippi Betting Lines
The latest college football betting odds favor Ole Miss to win at home, though Missouri’s underdog moneyline offers a substantial payout.
Point Spread
- Missouri +6 (-110)
- Mississippi -6 (-110)
Moneyline
- Missouri +185
- Mississippi -225
Total Points
- Over 59 (-105)
- Under 59 (-115)
Ole Miss carries a -225 moneyline, meaning a $225 wager would generate $100 in profit. Missouri’s +185 odds offer a considerably larger potential return, with a successful $100 wager producing $185 in profit.
The six-point spread requires Mississippi to win by at least seven points to cover. Missouri gamblers can win their spread bet if the Tigers win outright or lose by five or fewer points, while a six-point Rebels victory results in a push.
The 59-point total also deserves consideration, particularly given Ole Miss’s recent offensive production. With both teams capable of generating explosive plays, bettors have several potential angles beyond the outright winner.
Why Missouri Will Beat Mississippi
Missouri has shown it can compete with quality opponents, and its recent defensive performances offer considerable encouragement. The Tigers held Texas A&M to just six points last weekend, delivering one of their most impressive victories of the season.
Head coach Eli Drinkwitz has built a physical football team that can control possession and disrupt opposing offenses. Missouri’s defensive front will be especially important against Ole Miss quarterback Trinidad Chambliss, whose mobility adds challenges for defenders.
Quarterback Austin Simmons must also deliver an efficient offense while avoiding costly turnovers. If Missouri can establish a consistent rushing attack and limit Mississippi’s offensive possessions, the Tigers could keep the contest within one score.
History also favors Missouri, which holds a 7-1 all-time series advantage. The Tigers won the previous meeting 38-27 in 2019, and Ole Miss hasn’t beaten Missouri since 1974.
Why Mississippi Will Beat Missouri
Ole Miss has one of the SEC’s most dangerous offenses, led by quarterback Trinidad Chambliss. The Rebels recently scored 52 points against Vanderbilt, with Chambliss throwing three touchdown passes in the convincing victory.
Mississippi also features talented offensive weapons, including running back Kewan Lacy and receiver Deuce Alexander. A mobile quarterback, explosive receivers, and a productive rushing attack could create significant matchup problems for Missouri’s defense.
Home-field advantage represents another important consideration. Ole Miss will play in front of a sold-out crowd at Vaught-Hemingway Stadium, where the atmosphere should be particularly intense for this nationally ranked conference matchup.
Missouri has struggled in recent road games against ranked opponents, making Saturday’s trip to Oxford an important test. The Rebels could capitalize on that weakness by establishing an early lead and forcing Missouri into obvious passing situations.
Our Missouri vs. Mississippi Betting Prediction
Missouri’s defense should keep this contest competitive, especially if the Tigers can pressure Chambliss and keep Mississippi from making explosive plays. However, containing the Rebels for four quarters will be difficult.
Ole Miss brings a more explosive offense and benefits from home-field advantage. We expect Missouri to stay competitive through the first half before Mississippi’s offensive weapons start creating separation in the final two quarters.
Our prediction: Ole Miss 34, Missouri 24
- College Football Odds Offered At Bovada (Bovada Review)
- Rock M Nation
